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acdA [2017-06-05 15:45:37]
function
fatty acid degradation
product
acyl-CoA dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids]Gene
Coordinates
3,813,246 → 3,814,385
The protein
Catalyzed reaction/ biological activity
Acyl-CoA ETF = 2,3-dehydroacyl-CoA reduced ETF (according to Swiss-Prot)Protein family
acyl-CoA dehydrogenase family (according to Swiss-Prot)Paralogous protein(s)
[protein|BA28DFBAF88A4994B0541D1FF2187312FDE1FA15|YngJ], [protein|F25CDDEBAFC72036664323619F5197D45E86BE9A|MmgC], [protein|B5325CBF1408E2CA227EB462092E209F4C87E797|FadE][SW|Cofactors]
FMN or FAD [Pubmed|21635694]Structure
[PDB|2Z1Q] (from ''Thermus thermophilus hb8'', 40% identity, 55% similarity)Expression and Regulation
Operons
genes
[gene|DEE0DA15EE9EA27BA8C332204E40D336324A111C|fadF]-[gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]-[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]
description
[Pubmed|17189250]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17189250], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR]: repression, [Pubmed|17189250], in [regulon|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR regulon]regulation
repressed in the absence of long-chain fatty acids ([protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR]) [Pubmed|17189250]view in new tabReferences
